Imunotherapy in gynaecological oncology
نویسندگان
چکیده
Imunoterapie cĂlĂ na nÄkolik zĂĄsadnĂch problĂŠmĹŻ v rozpoznĂĄvĂĄnĂ nĂĄdorovĂ˝ch bunÄk imunitnĂm systĂŠmem, jsou to: antigen-prezentujĂcĂ dendritickĂŠ buĹky, cytotoxickĂŠ T lymfocyty a nĂĄdorovĂŠ mikroprostĹedĂ. vstupuje do terapeutickĂŠho portfolia ke stĂĄvajĂcĂm lĂŠÄebnĂ˝m modalitĂĄm gynekologickĂŠ onkologie (onkologickĂĄ chirurgie, konvenÄnĂ chemoterapie, radioterapie cĂlenĂĄ lĂŠÄba) od 90. let 20. stoletĂ. MĂĄ svĂĄ specifika ohlednÄ projevu lĂŠÄebnĂŠ odpovÄdi, spektra neŞådoucĂch ĂşÄinkĹŻ identifikace pacientek, kterĂŠ budou z lĂŠÄby profitovat. Pro navozenĂ efektivnĂ odpovÄdi imunoterapeutika je tĹeba pĹedevĹĄĂm vysokĂĄ mutaÄnĂ nĂĄloĹž buĹkĂĄch infiltrace tkĂĄnÄ cytotoxickĂ˝mi (TIL). ObecnÄ lze postulovat, Ĺže imunologickĂŠho pohledu malignity charakteristickĂŠ nĂzkou nĂĄloŞà vysoce imunosupresivnĂm nĂĄdorovĂ˝m mikroprostĹedĂm (s vĂ˝jimkou nÄkterĂ˝ch hypermutovanĂ˝ch endometriĂĄlnĂch karcinomĹŻ cervikĂĄlnĂho karcinomu). Z tohoto dĹŻvodu se klinickĂ˝ch studiĂch ukĂĄzalo jako vĂ˝hodnÄjĹĄĂ kombinovat dosud znĂĄmĂŠ modality: radioterapii, chemoterapii, cĂlenou lĂŠÄbu imunoterapeutika. NejlepĹĄĂ vĂ˝sledky byly zatĂm popsĂĄny ve s pokroÄilĂ˝m karcinomem endometria uĹžitĂm kombinace antiangiogennĂho preparĂĄtu lenvatinibu checkpoint inhibitorem pembrolizumabem.
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ژورنال
عنوان ژورنال: Onkologie
سال: 2021
ISSN: ['1803-5345', '1802-4475']
DOI: https://doi.org/10.36290/xon.2021.019